DR. MOHD FADHLIZIL FASIHI BIN MOHD ALUWI

	Contact No. : 094245000 Gender : MALE Nationality : MALAYSIA Current Positon : DS13-A-PENSYARAH UNIVERSITI E-Mail : fasihi@ump.edu.my
ACADEMIC QUALIFICATION
. 2017 : IJAZAH KEDOKTORAN (DOCTORAL DEGREE), UNIVERSITI KEBANGSAAN MALAYSIA, BANGI . 2010 : IJAZAH SARJANA (MASTERS DEGREE), UNIVERSITI TEKNOLOGI MARA, CAWANGAN SHAH ALAM . 2006 : IJAZAH SARJANA MUDA (BACHELOR DEGREE), UNIVERSITI TEKNOLOGI MARA, CAWANGAN SHAH ALAM
EXPERTISE
EXPERT AREA MAJOR YEARS OF EXPERTISE LEVEL DRUG DISCOVERY NATURAL PRODUCT SYNTHESIS 8 SANGAT TINGGI MEDICINAL CHEMISTRY ORGANIC CHEMISTRY, COMPUTATIONAL CHEMISTRY, PHARMACEUTICAL CHEMISTRY 4 TINGGI
EMPLOYMENT HISTORY
EMPLOYER POST JOIN DATE RESIGN DATE STATUS Universiti Teknologi Mara PEMBANTU PENSYARAH 01/02/2008 31/12/2008 KONTRAK Universiti Kebangsaan Malaysia PEMBANTU PENYELIDIK 01/11/2012 31/12/2013 KONTRAK Universiti Malaya PEMBANTU PENYELIDIK 01/06/2017 12/01/2018 KONTRAK Universiti Teknologi Mara PASCA KEDOKTORAN 15/01/2018 30/03/2018 KONTRAK
RESEARCH
NO. TITLE ROLE START DATE END DATE STATUS 1. REPURPOSING FDA-APPROVED DRUGS FOR BREAST CANCER TREATMENT WITH MECHANISTIC INSIGHTS FROM IN SILICO AND IN VITRO STUDIES (RDU242749) Leader 01-NOV-2024 31-OCT-2025 Sedang Berjalan 2. REPURPOSING FDA-APPROVED DRUGS FOR BREAST CANCER TREATMENT WITH MECHANISTIC INSIGHTS FROM IN SILICO AND IN VITRO STUDIES (UIC241552) Leader 01-NOV-2024 31-OCT-2025 Sedang Berjalan 3. IDENTIFICATION OF CHEMOPREVENTIVE POTENTIAL COMPOUNDS AND CHROMATOGRAPHIC FINGERPRINT DEVELOPMENT OF SCORODOCARPUS BORNEENSIS BECC Member 01-SEP-2024 31-AUG-2026 Sedang Berjalan 4. FUNDAMENTAL INSIGHT OF DEMETHOXYCURCUMIN LOADED WITH EDIBLE-NEST SWIFTLET/PVA NANOFIBERS FOR ANTIDIABETIC POTENTIAL Leader 01-SEP-2024 31-AUG-2026 Sedang Berjalan 5. WONDERS OF HYDROCARBONS Leader 01-JUN-2024 31-MAY-2025 Sedang Berjalan 6. EVALUATION OF NUTRITIVE AND NON-NUTRITIVE SWEETENERS RATIO INTAKE ON INFLAMMATION AND GUT MICROBIOTA IN A RAT MODEL. Member 01-DEC-2023 30-NOV-2025 Sedang Berjalan 7. FUNCTIONAL RESPONSES OF VOLATILE ORGANIC COMPOUND INVOLVE IN MEDIATING POLLINATION PROCESS OF OIL PALM FLOWERS (ELAEIS GUINEENSIS)AND ITS GENES EXPRESSION IN YEAST SYSTEM Member 07-SEP-2021 06-SEP-2024 Tamat (Laporan akhir dalam semakan) 8. CHEMOPREVENTIVE EFFECTS OF Α,Β-UNSATURATED CONTAINING COMPOUNDS ON BREAST CANCER: A VIRTUAL HIGH THROUGHPUT SCREENING STUDIES TARGETING MTOR SIGNALLING PATHWAY Leader 01-JUN-2021 31-MAY-2023 Tamat (Perlu hantar laporan akhir) 9. SYNTHESIS OF PYRAZOLE HYBRID OF USNIC ACID ANALOGUES AND THEIR PRELIMINARY CYTOTOXICITY EVALUATION AGAINST BREAST CANCER, COLORECTAL AND LUNG CANCER CELL LINES Leader 10-DEC-2020 09-DEC-2022 Tamat (Perlu hantar laporan akhir) 10. Effect of ligands on the solubility and photoacoustic coefficients of molecularly engineered porphyrins Member 01-SEP-2019 31-MAY-2023 Selesai (Tidak Mencapai KPI) 11. Evaluation of In Silico and Chemopreventive effects on Breast Cancer Cell lines of Novel Flavonoid Hybrid of Usnic Acid Derivatives Leader 01-SEP-2019 31-MAY-2022 Selesai (Tidak Mencapai KPI) 12. DESIGN, SYNTHESIS AND IN SILICO EVALUATION OF NOVEL ANTI-DENV FROM THE LEAD OF USNIC ACID Leader 05-SEP-2018 04-DEC-2020 Selesai (Mencapai Sebahagian KPI)
PUBLICATION
TYPE PUBLICATION TARIKH PENERBITAN TYPE OF CONTRIBUTION REFEREED PUBLICATION JOURNAL Exploration of leads from bis-indole based triazine derivatives targeting human aldose reductase in diabetic type 2: in-silico approaches 11/12/2024 corresponding author JOURNAL A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer 01/07/2024 co-author JOURNAL An In-Silico Approach to Evaluate Bioactive Molecules of Aloe Vera Leaf Extracts in Inhibiting the Glycogen Synthase Kinase-3β (GSK3-β) Protein for Faster Diabetic Wound Healing Potential 21/07/2024 corresponding author JOURNAL An eco-friendly and new facile method for synthesis of prenylated or geranylated acylphloroglucinol-based xanthenones 28/06/2024 Co-author JOURNAL Cancer drug resistance is a serious threat in Bangladesh 30/01/2024 Corresponding author JOURNAL Combat against antibiotic resistance is a challenge in Bangladesh 14/02/2024 corresponding author JOURNAL Comprehending the pharmacological mechanism of marine phenolic acids in bladder cancer therapy against matrix metalloproteinase 9 protein by integrated network pharmacology and in-silico approaches 14/07/2024 Corresponding author JOURNAL Computational Screening of FDA-Approved Hepatitis C Drugs for Inhibition of VEGFR2 in Liver Cancer 16/09/2024 Corresponding author JOURNAL Computational studies demonstrating dithymoquinone of Nigella sativa as a potential anti-dengue agent: Short review 20/02/2024 Corresponding author JOURNAL Concerns regarding SARS-CoV-2 JN. 1 mutations should be raised 14/05/2024 Corresponding author JOURNAL Cu (II) complexes based on benzimidazole ligands: synthesis, characterization, DFT, molecular docking & bioactivity study 12/11/2024 co-author JOURNAL Curcumin, a bioactive compound of Turmeric (Curcuma longa) and its derivatives as α-amylase and α-glucosidase inhibitors 08/08/2024 Corresponding author JOURNAL Dengue Death Rate Higher Among Women than Men in Bangladesh 03/06/2024 corresponding author JOURNAL Design, synthesis, structural characterization, cytotoxicity and computational studies of Usnic acid derivative as potential anti-breast cancer agent against MCF7 and T47D cell lines 02/12/2024 corresponding author JOURNAL Discovery of COVID-19 Protein Inhibitors in Phenolic Acids of Azadirachta indica (Neem) using Docking and Pharmacokinetics 25/09/2024 corresponding author JOURNAL Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages 11/01/2024 co-author JOURNAL Identification of β-cycloidal-derived mono-carbonyl curcumin analogs as potential interleukin-6 inhibitor to treat wound healing through QSAR, molecular docking, MD simulation, MM-GBSA calculation 23/03/2024 co-author JOURNAL Identification of Potent New Brain Cancer EGFR Inhibitor from Usimine A and Usimine B: Computer Aided Drug Design Perspective 24/08/2024 corresponding author JOURNAL In Silico Exploration of Isoxazole Derivatives of Usnic Acid: Novel Therapeutic Prospects Against α-Amylase for Diabetes Treatment 17/07/2024 corresponding author JOURNAL In vitro and in silico insights into the soybean 15-lipoxygenase inhibition with a new C-geranylated chalcone-based flavanone 28/11/2024 co-authos JOURNAL Insights from in silico exploration of major curcumin analogs targeting human dipeptidyl peptidase IV 24/01/2024 corresponding author JOURNAL Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis 10/04/2024 co-author JOURNAL Oropouche fever outbreak is emerging concern in American countries 02/08/2024 Corresponding author JOURNAL Phenolic compounds of Theobroma cacao L. show potential against dengue RdRp protease enzyme inhibition by In-silico docking, DFT study, MD simulation and MMGBSA calculation 14/03/2024 co-author JOURNAL Record dengue deaths in Bangladesh as disease patterns change 15/05/2024 Corresponding author JOURNAL Stereospecific α-glucosidase inhibition, kinetics, and molecular docking studies on isolated diastereomeric alkaloids from Uncaria longiflora 26/11/2024 co-author JOURNAL The importance of in-silico studies in drug discovery 04/02/2024 Corresponding author JOURNAL Theoretical investigation of selective inhibitory activity of chromone-based compounds against monoamine oxidase (MAO)-A and -B 05/12/2024 co-author CONFERENCE PAPER In silico Analysis for Discovery of Dengue Virus Inhibitor from Natural Compounds 02/01/2023 corresponding author JOURNAL (Z)-Benzyl 2-(5-methyl-2-oxoindolin-3-ylidene)- hydrazinecarbodithioate 12/09/2023 co-author JOURNAL Anti-diabetic Activity of Phloretin Against Maltase-glucoamylase Using Docking, Pharmacokinetics and Pharmacophore Studies 30/09/2023 corresponding author JOURNAL Computational evaluation of quinones of Nigella sativa L. as potential inhibitor of dengue virus NS5 methyltransferase 26/08/2023 Corresponding author JOURNAL Computer-aided anti-cancer drug discovery of EGFR protein based on virtual screening of drug bank, ADMET, docking, DFT and molecular dynamic simulation studies 07/09/2023 corresponding author JOURNAL Exploring the potential of biologically active phenolic acids from marine natural products as anticancer agents targeting the epidermal growth factor receptor 22/10/2023 corresponding author JOURNAL Identification of Pyrazole Derivatives of Usnic Acid as Novel Inhibitor of SARS-CoV-2 Main Protease Through Virtual Screening Approaches 08/02/2023 corresponding author JOURNAL In silico Study of Thiourea Derivatives as Potential Epidermal Growth Factor Receptor Inhibitors 09/01/2023 co-author JOURNAL In silico evaluation of usnic acid derivatives to discover potential antibacterial drugs against DNA gyrase B and DNA topoisomerase IV 18/02/2023 corresponding author JOURNAL In-Silico Studies of Usnic Acid against DENV-3 Methyltransferase 15/06/2023 corresponding author JOURNAL In-silico Design of Curcumin Analogs as Potential Inhibitors of Dengue Virus NS2B/NS3 Protease 20/04/2023 corresponding author JOURNAL Mefenamic acid inhibit transforming growth factor-beta type-1: Repurposing anti-inflammatory drugs in wound healing using in-silico approaches 25/11/2023 Corresponding author JOURNAL Molecular docking and drug-likeness study of nirmatrelvir as promising drug candidates of dengue virus NS2B-NS3 protease 01/03/2023 corresponding author JOURNAL Pharmacophore-based Molecular Docking of Usnic Acid Derivatives to Discover Anti-viral drugs Against Influenza A Virus 01/05/2023 corresponding author JOURNAL Pharmacophore-based virtual screening and in-silico study of natural products as potential DENV-2 RdRp inhibitors 01/01/2023 corresponding author JOURNAL Polypharmacological assessment of Amoxicillin and its analogues against the bacterial DNA gyrase B using molecular docking, DFT and molecular dynamics simulation 03/10/2023 Corresponding author JOURNAL Selected phytochemicals of Momordica charantia L. as potential anti-DENV-2 through the docking, DFT and molecular dynamic simulation 07/09/2023 corresponding author JOURNAL Synthesis, crystal structure and Hirshfeld surface analysis of ethyl 4-hydroxy-2-(4-hydroxyphenyl)-1-methyl-5-oxo-2, 5-dihydro-1H-pyrrole-3-carboxylate 11/07/2023 co-author JOURNAL Usnic Acid as Potential Inhibitors of BCL2 and P13K Protein through Network Pharmacology-based Analysis, Molecular Docking and Molecular Dynamic Simulation 03/02/2023 corresponding author JOURNAL Virtual screening of bioactive anti-SARS-CoV natural products and identification of 3β,12-diacetoxyabieta-6,8,11,13-tetraene as a potential inhibitor of SARS-CoV-2 virus and its infection related pathways by MD simulation and network pharmacology 28/02/2023 corresponding author BOOK CHAPTER Role of turmeric and cinnamon spices in digestive, metabolic, and immune systems 01/01/2022 30% (co-author) JOURNAL A SHORT REVIEW ON THE INFLUENCE OF THE PREPARATION METHOD ON THE PHYSICOCHEMICAL PROPERTIES OF Mg/Al HYDROTALCITE FOR GLUCOSE ISOMERIZATION 28/04/2022 co-author JOURNAL Identification of Novel 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors by an Integrated Method of Pharmacophore Virtual Screening, Docking, QSAR and ADMET Analyses 07/10/2022 Corresponding author JOURNAL Molecular Docking and in silico Evaluation of Phytochemicals of Bioactive Methanolic Extract of Ipomoea mauritiana Jacq. as Anti-Bacterial Agents 24/03/2022 corresponding author JOURNAL PHARMACOPHORE-BASED MOLECULAR DOCKING AND IN-SILICO STUDY OF NOVEL USNIC ACID DERIVATIVES AS AVIAN INFLUENZA A (H7N9) INHIBITOR 15/11/2022 corresponding author JOURNAL RECENT DEVELOPMENT ON THE SYNTHESIS OF THIOUREA DERIVATIVES AND EFFECT OF SUBSTITUENTS ON THE ANTICANCER ACTIVITY: A SHORT REVIEW 30/10/2022 co-author JOURNAL Structure-Based Virtual Screening Towards The Discovery of Usnic Acid Derivatives as Novel mTOR Inhibitor to Treat Breast Cancer 21/12/2022 corresponding author JOURNAL In Silico Functional and Structural Insight of Prenylated Pyrazolocurcumin Derivative Associated with the PGE2 Inhibition through mPGES-1 Blocking 30/03/2021 Corresponding author JOURNAL Pharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of Combretum indicum against Oxidative Stress and Alloxan-Induced Diabetes in Long–Evans Rats 30/07/2021 10% JOURNAL Qualitative dataset on UPLC-QTOF/MS tentative identification of phytochemicals from bioactive extract of Ipomoea mauritiana Jacq. 01/04/2021 10% JOURNAL Virtual Screening-based Identification of Potent DENV-3 RdRp Protease Inhibitors via in-house Usnic Acid Derivatives Database 09/10/2021 Corresponding author JOURNAL Antioxidant and antibacterial activity of Ipomoea mauritiana Jacq.: a traditionally used medicinal plant in Bangladesh 30/05/2020 10% JOURNAL Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking analysis 01/11/2020 10% JOURNAL Immunosuppressive and antibacterial activities of dihydromorin and norartocarpetin isolated from Artocarpus heterophyllus heartwoods 29/06/2020 10 (molecular docking part) JOURNAL PCSK9 inhibitory activity of marine-derived compounds, aaptaminoids, and benzamide originated from Aaptos aaptos and Acanthaster planci as a potential treatment for atherosclerosis 05/08/2020 10% JOURNAL Synthesis, In Silico Molecular Docking Modeling and Pharmacophore Mapping of (E)-3-(4-Hydroxy-2,6-Dimethoxyphenyl)-1-Phenylprop-2-en-1-One as Potential New Inhibitor of Microsomal Prostaglandin E2 Synthase-1 27/03/2020 main author and corresponding author JOURNAL Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA 05/07/2019 45% (Main author and corresponding author) JOURNAL In vitro cytotoxicity of Clinacanthus nutans fractions on breast cancer cells and molecular docking study of sulphur containing compounds against caspase-3 15/10/2019 20% co-author JOURNAL Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: Synthesis, biological activity, crystal structure analysis, and molecular docking studies 24/10/2019 co-author JOURNAL Insights on the synthesis of asymmetric curcumin derivatives and their biological activities 14/09/2019 25% co-author JOURNAL Palladium-Catalysed Cross-Coupling Reactions for the Synthesis of Chalcones 27/06/2019 10% - co author JOURNAL Oestrogenic activity of mimosine on MCF‐7 breast cancer cell line through the ERα‐mediated pathway 24/09/2018 20% (co-author)